The adenovirus (AdV) usually refers to a class of DNA virus belonging to the genus of Human Mastadenovirus and the family of the Adenoviridae. AdV has a broad range of hosts causing a wide range of infections in humans, such as mild respiratory infections, pneumonia, follicular conjunctivitis, gastroenteritis. Discovered in 1953, AdV was named after the first isolation from human adenoid tissues. Up to now, more than 100 distinct adenoviral serotypes have been identified, among which about 51 types are common pathogens of humans and animals. Currently, AdV is more often used as a tool in molecular biological research and a viral vector for gene therapy due to its stable infectivity of human and other mammalian cells.