ADGRL4 Membrane Protein
Adhesion G protein-coupled receptor L4 (ADGRL4), also known as ETL, ELTD1 or KPG_003, is encoded by the ELTD1 gene. Based on its sequence, ADGRL4 is a member of the secretin family of G protein-coupled peptide hormone receptors and belongs to the epidermal growth factor 7-transmembrane (EGF-TM7) subfamily. ADGRL4 plays a role in angiogenesis, both physiological and pathological, as well as glioblastoma and the protein levels of ADGRL4 are significantly higher in humans and rodent gliomas. Structurally, it contains a large extracellular domain with EGF-like repeats, a seven transmembrane domain, and a short cytoplasmic tail.