ADORA3 Membrane Protein
Adenosine receptor A3 (ADORA3) is a protein that in humans is encoded by the ADORA3 gene. The gene contains 2 exons separated by a single intron of about 2.2 kb. The A3 adenosine receptor is found to be expressed in Chinese hamster ovary cells and the agonist binds to membrane preparations inhibited cAMP accumulation. Pharmacologic characterization with several adenosine receptor agonists and xanthine antagonists showed that the human receptor is more similar to the sheep A3 adenosine receptor than to the rat A3 adenosine receptor. Adenosine released during cardiac ischemia exerts an effective, protective effect in the heart.