Changes to Chromosome Structure
Next Generation: HS.LS3.2 HS.LS3.2

Changes to Chromosome Structure


This lesson will identify how the structure of a chromosome can change and the implications that come from changes in chromosomes.

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Images Used: Cri-du-chat; Creative Commons: http://en.wikipedia.org/wiki/File:Criduchat.jpg Translocation Karyotype; Public Domain: http://commons.wikimedia.org/wiki/File:Karyotype.Translocation%2BDeletion.Schematic.gif Karyotype; Public Domain: http://en.wikipedia.org/wiki/File:Human_karyotype.svgtranslocation;PublicDomain:http://upload.wikimedia.org/wikipedia/commons/c/cb/Translocation-4-20.png

  • Deletion

    When part of a chromosome is deleted; sometimes it may not have any effect while other times it does.

  • Cri-du-chat

    A genetic disorder caused by the deletion of a section of the 5th chromosome; cri-du-chat is French for “cry of the cat”. Cri-du-chat causes physical and cognitive abnormalities.

  • Translocation

    A chromosome abnormality that occurs when nonhomologous parts rearrange and fuse together.

  • Duplication

    Sequences of nucleotides are repeated multiple times, they haven’t been linked to disorders, but have been linked to cancers.

  • Karyotype

    Looking at the number of chromosomes and their characteristics under a microscope, this is a critical tool in assessing genetic disorders in a developing embryo.