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Changes to Chromosome Structure
Next Generation: HS.LS3.2 HS.LS3.2

Changes to Chromosome Structure

Description:

This lesson will identify how the structure of a chromosome can change and the implications that come from changes in chromosomes.

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Tutorial

Images Used: Cri-du-chat; Creative Commons: http://en.wikipedia.org/wiki/File:Criduchat.jpg Translocation Karyotype; Public Domain: http://commons.wikimedia.org/wiki/File:Karyotype.Translocation%2BDeletion.Schematic.gif Karyotype; Public Domain: http://en.wikipedia.org/wiki/File:Human_karyotype.svgtranslocation;PublicDomain:http://upload.wikimedia.org/wikipedia/commons/c/cb/Translocation-4-20.png

Terms to Know
Cri-du-chat

A genetic disorder caused by the deletion of a section of the 5th chromosome; cri-du-chat is French for “cry of the cat”. Cri-du-chat causes physical and cognitive abnormalities.

Deletion

When part of a chromosome is deleted; sometimes it may not have any effect while other times it does.

Duplication

Sequences of nucleotides are repeated multiple times, they haven’t been linked to disorders, but have been linked to cancers.

Karyotype

Looking at the number of chromosomes and their characteristics under a microscope, this is a critical tool in assessing genetic disorders in a developing embryo.

Translocation

A chromosome abnormality that occurs when nonhomologous parts rearrange and fuse together.