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Chapter 03: General Pharmacokinetic and Pharmacodynamic Principles Test Bank

Chapter 03: General Pharmacokinetic and Pharmacodynamic Principles Test Bank

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Chapter 03: General Pharmacokinetic and Pharmacodynamic Principles
Test Bank
MULTIPLE CHOICE
1.   A primary care nurse practitioner (NP) prescribes a drug to an 80-year-old African-American woman. When selecting a drug and determining the correct dose, the NP should understand that the knowledge of how age, race, and gender may affect drug excretion is based on an understanding of:
a.

bioavailability.

b.

pharmacokinetics.

c.

pharmacodynamics.

d.

anatomy and physiology.

2.   A patient asks the primary care NP which medication to use for mild to moderate pain. The NP should recommend:
a.

APAP.

b.

Tylenol.

c.

acetaminophen.

d.

any over-the-counter pain product.

3.   A patient wants to know why a cheaper version of a drug cannot be used when the primary care NP writes a prescription for a specific brand name of the drug and writes, “Dispense as Written.” The NP should explain that a different brand of this drug:
a.

may cause different adverse effects.

b.

does not necessarily have the same therapeutic effect.

c.

is likely to be less safe than the brand specified in the prescription.

d.

may vary in the amount of drug that reaches the site of action in the body.

4.   A primary care NP wishes to order a drug that will be effective immediately after administration of the drug. Which route should the NP choose?
a.

Rectal

b.

Topical

c.

Sublingual

d.

Intramuscular

5.   A patient receives an inhaled corticosteroid to treat asthma. The patient asks the primary care NP why the drug is given by this route instead of orally. The NP should explain that the inhaled form:
a.

is absorbed less quickly.

b.

has reduced bioavailability.

c.

has fewer systemic side effects.

d.

provides dosing that is easier to regulate.

6.   A patient takes an oral medication that causes gastrointestinal upset. The patient asks the primary care NP why the drug information insert cautions against using antacids while taking the drug. The NP should explain that the antacid may:
a.

alter drug absorption.

b.

alter drug distribution.

c.

lead to drug toxicity.

d.

increase stomach upset.

7.   A patient will begin taking two drugs that are both protein-bound. The primary care NP should:
a.

prescribe increased doses of both drugs.

b.

monitor drug levels, actions, and side effects.

c.

teach the patient to increase intake of protein.

d.

stagger the doses of drugs to be given 1 hour apart.

8.   A patient is taking drug A and drug B. The primary care NP notes increased effects of drug B. The NP should suspect that in this case drug A is a cytochrome P450 (CYP450) enzyme:
a.

inhibitor.

b.

substrate.

c.

inducer.

d.

metabolizer.

9.   The primary care NP should understand that a drug is at a therapeutic level when it is:
a.

at peak plasma level.

b.

past 4 or 5 half-lives.

c.

at its steady plasma state.

d.

between minimal effective concentration and toxic levels.

10.   A primary care NP is preparing to prescribe a drug and notes that the drug has nonlinear kinetics. The NP should:
a.

monitor frequently for desired and adverse effects.

b.

administer a much higher initial dose as a loading dose.

c.

monitor creatinine clearance at baseline and periodically.

d.

administer the drug via a route that avoids the first-pass effect.

11.   A primary care NP is prescribing a drug for a patient who does not take any other medications. The NP should realize that:
a.

CYP450 enzyme reactions will not interfere with this drug’s metabolism.

b.

substrates such as alcohol cannot interfere with the drug when the patient is abstaining.

c.

food-drug interactions are limited to those where food enhances or inhibits drug absorption.

d.

a thorough history of diet, alcohol use, smoking, and over-the-counter and herbal products is required.


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