Author: Christine Farr


COH 315: Principles of EpidemiologyCalculations and Interpretations: Answer the following questions in the space provided. Showall of your work.1. Evidence of an increased risk of lung cancer associated with cigarette smoking wassought by Doll and Hill. In one study, 649 lung cancer cases were matched by age, andgender to 649 controls; 647 of the cases and 622 of the control had a history of smokingcigarettes.a. Name the type of study.b. Create the appropriate 2X2 table for the study. (2 points)Lung Cancer ControlsSmokers6472Total27649Nonsmokers622649c. Calculate the appropriate measure of association for the study. (4 points)d. Interpret the results. (2 points)2. In another study, the smoking habits of 34,445 male physicians were obtained by mailedquestionnaires. Deaths among these physicians over the subsequent years wereidentified though contact with the office of the Registrar General. The death rates fromlung cancer of these physicians classified by smoking habits were :Standardized Death Rates per 1000 Persons Aged 35 or More perYearNonsmokers0.07Cigarette Smokers0.96a. Name the type of study. (2 points) b. Calculate the Relative Risk for smokers as compared to nonsmokers. (6 points)c. Interpret the results (2 points)Annual Death Rates per 100,000 PersonsExposure CategoryLung CancerHeavy SmokersNonsmokersCoronary Heart Disease1667599422a. Calculate the relative risk from Lung Cancer Mortality for Heavy Smokers compared tonon smokers. ( 4 points)b. Calculate the attributable risk of Lung Cancer from smoking. (4 points)c. Interpret the results. (2 points)d. Calculate the percent attributable risk of Coronary Heart Disease due to smoking (4points)e. Interpret the results. (2 points)3. Convert the following incidence rates to attributable risk using the additive model: (5points) Incidence RatesRelative RisksFactor AFactor A_Factor B -+3.0_+9.0_______________________________________________________________________+15.021.004. Calculate the concordance rate for the following data: (5 points)Twin 1Has LeukemiaTwin 2Does Not Have LeukemiaHas Leukemia141Does Not Have Leukemia2636

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