Coronavirus Homology Modeling
The analysis of three-dimensional (3D) structure is of great importance for the mechanism of virus infection and the design of antiviral drugs. Although many breakthroughs have been made in structural biology techniques and structure determination methods such as X-ray crystallography, NMR spectroscopy and cryo-electron microscopy (cryo-EM) have been utilized to determine the structure of many biological macromolecules, the process of obtaining the 3D structure of the target protein is still difficult and time-consuming. Facing the continuous spread of the epidemic, we need to accelerate the understanding of the pathogenic mechanism of the virus. Creative Biostructure can generate structural models of coronavirus/host proteins through calculation methods, which will be a powerful alternative and supplement to the experimental method.