Coxsackieviruses, the leading causes of aseptic meningitis, are a few related enteroviruses that belong to the Picornaviridae family of non-enveloped, linear, positive-sense single-stranded RNA viruses. Coxsackieviruses are divided into group A and group B viruses based on early observations of their pathogenicity in neonatal mice. Group A coxsackieviruses (CVA) were noted to cause a flaccid paralysis while group B coxsackieviruses (CVB) were noted to cause a spastic paralysis. At least 23 serotypes (1-22, 24) of CVA and six serotypes (1-6) of CVB are recognized. The most studied serotypes are CVB3, CVA6, and CVA16.