Online College Courses for Credit

E3 ligase protein

E3 ligase protein

Author: creative biolabs

E3 ligase protein

The ubiquitin-proteasome system (UPS) plays key roles in our cellular system by participating in regulating protein quality control and general protein homeostasis. As an irreplaceable component, the E3 ubiquitin ligase also functions in proteolysis targeting chimeras (PROTACs) with the help of E3 ligase ligands. However, only a limited number of E3 ubiquitin ligases have been successfully used in this high-ending technology: the Von Hippel-Lindau disease tumor suppressor protein (VHL), the Mouse Double Minute 2 homologue (MDM2), the Cellular Inhibitor of Apoptosis (cIAP), and cereblon. Since more than 600 E3 ubiquitin ligases in human proteome have been identified, it’s great potential to try more new ligases in the PROTAC molecule development. Creative Biolabs has produced several E3 ubiquitin ligases and customers could conduct in vitro function tests of their preliminary PROTAC molecules. We are also working to develop more E3 ubiquitin ligases by incorporating our cell-free protein expression system.

See More
Fast, Free College Credit

Developing Effective Teams

Let's Ride
*No strings attached. This college course is 100% free and is worth 1 semester credit.

37 Sophia partners guarantee credit transfer.

299 Institutions have accepted or given pre-approval for credit transfer.

* The American Council on Education's College Credit Recommendation Service (ACE Credit®) has evaluated and recommended college credit for 32 of Sophia’s online courses. Many different colleges and universities consider ACE CREDIT recommendations in determining the applicability to their course and degree programs.