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Kidney Function Case Study

Author: Meg O'Mahony

Grandma’s TUM-my Trouble: A Case Study in Renal Physiology and Acid-Base Balance

You will be using this Case Study which requires an understanding of both kidney function and blood buffering systems.  It also gives you the opportunity to learn more specific details about some of the transport mechanisms in the distal and proximal convoluted tubules.

This case study was written by Ann T. Massey (Nell Hodgson Woodruff School of Nursing, Emory University, Atlanta, GA) and is posted on the Buffalo University National Center for Case Study Teaching in Science. Please go to the site: http://sciencecases.lib.buffalo.edu/cs/collection/detail.asp?case_id=731&id=731  and download the case study from there.

Source: Ann T. Massey, Nell Hodgson Woodruff School of Nursing, Emory University National Center for Case Study Teaching in Science

Rubric for Kidney Function Case Study

This is the rubric that will be used to grade your answers to this case study. The relevant case study questions are sorted as to KU, TI, A and C. Notice that the Thinking/Inquiry is distinguishes between Process and Strategic Thinking.

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Source: M. O'Mahony

NIH - Diabetes, Digestive and Kidney Diseases

http://www.niddk.nih.gov/health-information/Pages/default.aspx

This page from the National Institutes of Health (US) is a good resource for information about kidney problems relevant to the case study.

Source: NIH: Diabetes, Digestive and Kidney Disorders

Useful Pictures

I found the figures in the case study to be a little bit confusing.  It shows the cell that would be part of the proximal and distal tubule walls.

Here are some figures that I found useful understanding which way the ions were being transported - and what they were being transported into and out of.

http://www.zuniv.net/physiology/book/images/25-9.jpg

http://en.wikivet.net/Reabsorption_and_Secretion_Along_the_Proximal_Tubule_-_Anatomy_%26_Physiology

http://www.pathwaymedicine.org/proximal-tubule-transport

https://www.google.ca/search?q=sodium+reabsorption+in+the+proximal+convoluted+tubule&sa=G&biw=968&bih=543&tbm=isch&imgil=lfg-bMP1zaGkwM%253A%253BC2Y_SvOfQMiGeM%253Bhttp%25253A%25252F%25252Fintranet.tdmu.edu.ua%25252Fdata%25252Fkafedra%25252Finternal%25252Fpharmakologia%25252Fclasses_stud%25252Fen%25252Fpharm%25252Fprov_pharm%25252Fptn%25252FPharmacology%25252F3%2525252520year%25252F15%2525252520Diuretics%2525252520Stimulants%2525252520and%2525252520relaxants.htm&source=iu&pf=m&fir=lfg-bMP1zaGkwM%253A%252CC2Y_SvOfQMiGeM%252C_&usg=__caNP-4z2IQ7CQJ47PtxcRKqGA78%3D&ved=0CCkQyjc&ei=j6ADVd-ZM7TLsAST7IDIAQ#imgrc=lfg-bMP1zaGkwM%253A%3BC2Y_SvOfQMiGeM%3Bhttp%253A%252F%252Fbasic-clinical-pharmacology.net%252Fchapter%25252015_%252520diuretic%252520agents_files%252Fimage007.gif%3Bhttp%253A%252F%252Fintranet.tdmu.edu.ua%252Fdata%252Fkafedra%252Finternal%252Fpharmakologia%252Fclasses_stud%252Fen%252Fpharm%252Fprov_pharm%252Fptn%252FPharmacology%252F3%252520year%252F15%252520Diuretics%252520Stimulants%252520and%252520relaxants.htm%3B413%3B438

http://o.quizlet.com/FHkL-yaQIVK5Fs1WeEZoaw_m.png

http://apbrwww5.apsu.edu/thompsonj/Anatomy%20&%20Physiology/2020/2020%20Exam%20Reviews/Exam%204/sec.act.transport.antiporter-x.jpg

http://arbl.cvmbs.colostate.edu/hbooks/pathphys/endocrine/thyroid/calcium.html

http://www.nature.com/nrrheum/journal/v8/n11/images/nrrheum.2012.157-f3.jpg

http://upload.wikimedia.org/wikipedia/commons/5/5c/1817_The_Role_of_Parathyroid_Hormone_in_Maintaining_Blood_Calcium_Homeostasis.jpg

 

Source: given above