Natriuretic peptide (NP) is a peptide that causes renal sodium excretion by the kidney. What’s more, it plays a very significant role in the regulation of extracellular fluid, electrolyte balance, and blood pressure. On one hand, it can affect the internal environment by their function such asdiuresis, natriuresis, vasodilation, inhibition of the sympathetic system and complex interaction with vasopressin and cytokines. On the other hand, the natriuretic peptide family is consists of an atrial natriuretic peptide, brain natriuretic peptide, C-type natriuretic peptide, Dendroaspis natriuretic peptide, and urodilatin. They play an important role in the diagnosis of some diseases, especially in cardiovascular diseases. Meanwhile, with the help of type-C receptor, natriuretic peptides can be cleared from the circulation through endopeptidases present on the surface of epithelial cells, smooth muscles, myocytes, renal epithelium, and fibroblasts.