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Osteoporosis Pathogenesis

Osteoporosis Pathogenesis

Author: Aaron Mullally

- know the three major contributors to osteoporosis pathogenesis

- know what the various risk factors for osteoporosis are

- know the role that estrogen plays in the pathogenesis of osteoporosis

- know what happens to bone at the tissue level during osteoporosis

- know what the most common fracture sites are as a result of osteoporosis

This packet will go over the risk factors for osteoporosis and the pathologic changes of the bone tissue itself.

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Osteoporosis is a disease that is caused by an imbalance of the remodeling forces of bone. The imbalance favors the resorption or breakdown of bone. One of the major causes of osteoporosis is a severe drop in estrogen levels caused by menopause. Because of this osteoporosis dominates the femal gender. Here is a useful link with an animation that covers estrogen's role in bone remodeling:

Source: Mind of Aaron

Osteoporosis Pathogenesis

This video covers the risk factors of osteoporosis and how they apply to the pathogenesis of the disease.

Source: Self made

Osteoporosis Pathogenesis

Source: Self made

Estrogen Mechanisms

This is a peer reviewed article about the role of estrogen and bone remodeling