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peptide rna conjugation

peptide rna conjugation

Author: Dynah Perry

peptide rna conjugation

Peptide-RNA conjugate is considered a useful drug because its stability is much better than RNA. Methods for preparing peptide-RNA conjugates include: post-synthesis coupling method (or post-assembly coupling method and fragment coupling method), fully stepwise synthesis method (or online solid-phase synthesis method), natural coupling method and template orientation coupling method. For Peptide-RNA conjugates, 2'-O-methyl RNA is a recommended analog, which is resistant to degradation by single-stranded ribonuclease. Creative Peptides uses click chemistry to synthesize Peptide-RNA conjugates. Both peptides and oligonucleotides are first modified to perform biological orthogonal ligation reactions. These peptide-RNA conjugates are becoming more and more important in antisense therapy because they are identified as active carriers that can enhance the cell delivery of antisense oligonucleotides. RNA and peptide synthesis are produced and conjugated by our expert scientists in biological binding chemistry. According to strict biosynthesis quality assurance and quality control standards, every peptide-RNA conjugate is strictly monitored in every production cycle.

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