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Polygenic Traits and Pleiotropy

Polygenic Traits and Pleiotropy

Author: Aaron Mullally
Description:

This lesson will explain what a polygenic trait is and give examples of polygenic and pleiotropy traits.

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Tutorial

Notes on "Polygenic Traits and Pleiotropy"

Overview

(00:00-00:53) Key Terms

(00:54-01:26) Polygenic Trait

(01:27-02:55) Continuing Variation

(02:56-05:20) Sickle-Cell Anemia


Source: Aaron M

Terms to Know
Continuous Variation

Variation of a trait that shows up in a population of people, body height for instance.

Multifactorial Trait

A gene that is partially controlled by genetics and partially controlled by the environment. For example, body height is genetic but nutrition growing up also influences height.

Penetrance

The degree to which an inherited allele is expressed in the phenotype. An example would be achondroplastic dwarfism; if a person inherits the allele and it presents, they will be a dwarf.

Pleiotropy

When one gene influences multiple phenotypic traits. Examples would be sickle-cell anemia and phenylketonuria (PKU).

Polygenic Trait

A trait that is determined by several genes.

Sickle-cell Anemia

An example of pleiotropy, a person who inherits the mutated HBs gene will contract sickle-cell anemia which damages erythrocytes, the spleen and many other organs of the body.